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A native of Gonzales County, Dr. George Holmes (1881-1948) began practicing medicine in Gonzales in 1915. His dream of a fully equipped hospital for the county seat was realized with the completion of this hospital building in 1921. Constructed by contractor Fred Miesenhelder, the two-story red brick building features a Spanish tile roof and a bracketed porch. It served as hospital and administrative offices until 1978. Recorded Texas Historic Landmark – 1984
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